Archives For oncoviruses

images

The human cytomegalovirus (HCMV) and glioma sym- posium was convened on April 17, 2011 in Washington, DC, and was attended by oncologists and virologists involved in studying the relationship between HCMV and gliomas. The purpose of the meeting was to reach a consensus on the role of HCMV in the pathology of gliomas and to clarify directions for future research. First, the group summarized data that describe how HCMV biology overlaps with the key pathways of cancer. Then, on the basis of published data and ongoing research, a consensus was reached that there is sufficient evidence to conclude that HCMV sequences and viral gene expression exist in most, if not all, malig- nant gliomas, that HCMV could modulate the malig- nant phenotype in glioblastomas by interacting with key signaling pathways; and that HCMV could serve as a novel target for a variety of therapeutic strategies. In summary, existing evidence supports an oncomodula- tory role for HCMV in malignant gliomas, but future studies need to focus on determining the role of HCMV as a glioma-initiating event.

HallmarksOfCancerList

https://www.dropbox.com/s/u0f80r60kc8qkh5/%28H%29%20Neuro%20Oncol-2012-Dziurzynski-246-55.pdf

“HCMV can also do every one of the things that generally considered the 10 hallmarks ofcancer,” says Kalejta, a member of the McArdle Laboratory for Cancer Research, Carbone Cancer Center, Stem Cell and Regenerative Medicine Center and Institute for Molecular Virology at UW-Madison.

http://www.med.wisc.edu/news-events/new-evidence-links-virus-to-brain-cancer/32922

Advertisements

iStock_000011406696Small“Typically, this pathway is only active during embryonic growth and development,” Melnick said, “but when CMV turns it back on, the resulting growth is a malignant tumor that supports production of more and more of the virus.”

http://dentistry.usc.edu/2011/11/14/common-virus-conclusively-identified-as-cancer-causing-oncovirus-ostrow-school-of-dentistry-researchers-pinpoint-cytomegalovirus’-central-role-in-salivary-gland-cancer/

“We have confirmed the presence of active CMV infection in 99% of malignant Glioblastoma tumors and in 90% of Medulloblastoma and Neuroblastoma tumors.”

“Will Anti-Viral drugs give new hope for malignant Glioblastoma patients?”

http://www.cmm.ki.se/en/Research/Cardiovascular-and-Metabolic-Diseases/Cell-and-Molecular-Immunology/Cia/Our-research/CMV-infection-in-cancer/

Significant Association of Multiple Human Cytomegalovirus Genomic Loci with Glioblastoma Multiforme Samples

Not surprisingly, human cancer viruses can produce within cells one or more of the molecular hallmarks of cancer (10) that promote cellular plasticity (through genomic instability, inflammation, deregulation of cellular energetics, and induction of angiogenic and metastatic processes), proliferation (by sustaining proliferative signaling, evading growth suppressors, and enabling replicative immortality), and survival (avoidance of immune detection and inhibition of apoptosis).

“Sufficient evidence has emerged to suggest that HCMV could modulate the malignant phenotype in Glioblastomas , and elements of it’s biology overlap those considered to be the hallmarks of cancer.”

http://kalejta.virology.wisc.edu/sites/kalejta.virology.wisc.edu/files/Dziurzynski_et_al.pdf

“HCMV is the most common infection of human fetal brain, and HCMV was known to be able to persistently infect glioma cells and become reactivated in a chronic inflammatory state”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214144/pdf/2042-4280-2-10.pdf