Archives For Inflammation

iStock_000006391407XSmallMany factors contribute to Cancer, but the key catalyst (even the underlying engine) is one of many Viruses, particularly CMV, but also VZV, Epstein Barr as well as other Viruses SV-40, BK, JCV and HPV. Each cancer in our body has one to many viruses associated with it. Some key ones are HPV – Human Papilloma Virus causes Cervical, Anal, Mouth, Throat, Lung, Vaginal and Penile Cancers. Epstein Barr causes Lymphoma, JC Polyoma Virus causes Colon Cancer. Epstein Barr, HPV & CMV have all been associated with Breast Cancer, thus one reason for it’s prevalence. Now down to kids Cancer, Medulloblastoma Neuroblastoma and it’s 99% terminal twin cancer Glioblastoma. For these cancers its mainly CMV (Human Cytomegalovirus), though other viruses like SV-40, JC and BK are also capable and have been found in these tumors.

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“We have confirmed the presence of active CMV infection in 99% of malignant Glioblastoma tumors and in 90% of Medulloblastoma and Neuroblastoma tumors.”

“Will Anti-Viral drugs give new hope for malignant Glioblastoma patients?”

http://www.cmm.ki.se/en/Research/Cardiovascular-and-Metabolic-Diseases/Cell-and-Molecular-Immunology/Cia/Our-research/CMV-infection-in-cancer/

Ignition of a match, with smoke on dark backgroundCancers including Glioblastoma and Medulloblastoma over express the Cox-2 enzyme driving chronic inflammation and enabling the microenvironment for viruses like CMV and as well as cancer spread. Specific anti-inflammatories that target Cox-2 down regulation including Melatonin, Curcumin, Aspirin, Chokeberry/Aronia Berry and L-Lysine have been shown to help reduce cox-2 over expression.

https://www.dropbox.com/s/foz18g2jvs9i7gg/%28N%29%20HCMV-Cox2%20regulation.pdf

Significant Association of Multiple Human Cytomegalovirus Genomic Loci with Glioblastoma Multiforme Samples

Not surprisingly, human cancer viruses can produce within cells one or more of the molecular hallmarks of cancer (10) that promote cellular plasticity (through genomic instability, inflammation, deregulation of cellular energetics, and induction of angiogenic and metastatic processes), proliferation (by sustaining proliferative signaling, evading growth suppressors, and enabling replicative immortality), and survival (avoidance of immune detection and inhibition of apoptosis).

“Sufficient evidence has emerged to suggest that HCMV could modulate the malignant phenotype in Glioblastomas , and elements of it’s biology overlap those considered to be the hallmarks of cancer.”

http://kalejta.virology.wisc.edu/sites/kalejta.virology.wisc.edu/files/Dziurzynski_et_al.pdf