The following article explains how CMV or Cytomegalovirus recreates the Hallmarks of Cancer. The following are all signs of cancer: high prevalence of cell growth signaling, evading and disabling growth suppression, resisting cell death procedures, thus enabling cell immortality, building new blood vessels and enabling invasion and thus metastasis. Chronic inflammation also plays a role in cancer progression as well. Now see Hallmark by Hallmark how CMV can recreate all of these drivers that together enable cancer.
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Brain metastases caused by solid tumors in others parts of the body and cause many cancer related deaths. Human cytomegalovirus (HCMV or CMV) is recently been detected consistently using the latest methods reviewing brain metastases tumors from primary breast and colorectal cancers.
This report shows for the first time a very high prevalence of CMV infection in brain metastasis from both breast and colorectal cancers. CMV proteins now being proven to drive cancers were detected in 99% (n = 78) brain metastasis samples and also in 92% to 100% (n = 25) of corresponding breast and colorectal cancer specimens.
Patients who had low-grade CMV infections in the primary tumor or the brain metastasis had a longer time to tumor progression and overall longer survival (13.5 months Overall Survivial with low-grade infection compared to 6.9 months with high grade infections). Time to tumor progression was also longer with low-grade CMV infections at 65.1 months average versus 30 months with high-grade infection. Importantly, the presence of CMV in brain metastasis may open new treatment options as recently tests with Glioblastoma brain tumors have shown significant increases in survival by treating these highly prevalent CMV infected tumors with anti-virals like Valcyte.
Research also shows 94% of lymph node metastasis of breast cancer and 99% of brain metastasis of colorectal and breast cancers are CMV protein positive, but virus positivity is nearly absent in healthy surrounding tissues implying a viral presence in metastasis initiating cells.
Many factors contribute to Cancer, but the key catalyst (even the underlying engine) is one of many Viruses, particularly CMV, but also VZV, Epstein Barr as well as other Viruses SV-40, BK, JCV and HPV. Each cancer in our body has one to many viruses associated with it. Some key ones are HPV – Human Papilloma Virus causes Cervical, Anal, Mouth, Throat, Lung, Vaginal and Penile Cancers. Epstein Barr causes Lymphoma, JC Polyoma Virus causes Colon Cancer. Epstein Barr, HPV & CMV have all been associated with Breast Cancer, thus one reason for it’s prevalence. Now down to kids Cancer, Medulloblastoma Neuroblastoma and it’s 99% terminal twin cancer Glioblastoma. For these cancers its mainly CMV (Human Cytomegalovirus), though other viruses like SV-40, JC and BK are also capable and have been found in these tumors.
HCMV is found is 99%+ of Glioblastoma Brain Tumors. Researchers are now beginning to measure the level of CMV infection in the tumors as a prognostic marker for expected survival. The research shows that Low Levels of CMV in a Glioblastoma tumor correlates to survival beyond 18 months. Actively treating CMV in Glioblastoma has a direct and positive improvement in patients survival length. This issue needs further research and the same research applied to other cancers to improve their survival rates.
“Typically, this pathway is only active during embryonic growth and development,” Melnick said, “but when CMV turns it back on, the resulting growth is a malignant tumor that supports production of more and more of the virus.”
“We have confirmed the presence of active CMV infection in 99% of malignant Glioblastoma tumors and in 90% of Medulloblastoma and Neuroblastoma tumors.”
“Will Anti-Viral drugs give new hope for malignant Glioblastoma patients?”
Cancers including Glioblastoma and Medulloblastoma over express the Cox-2 enzyme driving chronic inflammation and enabling the microenvironment for viruses like CMV and as well as cancer spread. Specific anti-inflammatories that target Cox-2 down regulation including Melatonin, Curcumin, Aspirin, Chokeberry/Aronia Berry and L-Lysine have been shown to help reduce cox-2 over expression.