“During the last years increasing evidence implies that human cytomegalovirus (CMV) can be attributed to human malignancies arising from numerous tissues. In this perspective, we will review and discuss the potential mechanisms through which CMV infection may contribute to brain tumors by affecting tumor cell initiation, progression and metastasis formation. Recent evidence also suggests that anti-CMV treatment results in impaired tumor growth of CMV positive xenografts in animal models and potentially increased survival in CMV positive glioblastoma patients. Based on these observations and the high tumor promoting capacity of this virus, the classical and novel antiviral therapies against CMV should be revisited as they may represent a great promise for halting tumor progression and lower cancer deaths.”
Archives For CMV
The following article explains how CMV or Cytomegalovirus recreates the Hallmarks of Cancer. The following are all signs of cancer: high prevalence of cell growth signaling, evading and disabling growth suppression, resisting cell death procedures, thus enabling cell immortality, building new blood vessels and enabling invasion and thus metastasis. Chronic inflammation also plays a role in cancer progression as well. Now see Hallmark by Hallmark how CMV can recreate all of these drivers that together enable cancer.
Brain metastases caused by solid tumors in others parts of the body and cause many cancer related deaths. Human cytomegalovirus (HCMV or CMV) is recently been detected consistently using the latest methods reviewing brain metastases tumors from primary breast and colorectal cancers.
This report shows for the first time a very high prevalence of CMV infection in brain metastasis from both breast and colorectal cancers. CMV proteins now being proven to drive cancers were detected in 99% (n = 78) brain metastasis samples and also in 92% to 100% (n = 25) of corresponding breast and colorectal cancer specimens.
Patients who had low-grade CMV infections in the primary tumor or the brain metastasis had a longer time to tumor progression and overall longer survival (13.5 months Overall Survivial with low-grade infection compared to 6.9 months with high grade infections). Time to tumor progression was also longer with low-grade CMV infections at 65.1 months average versus 30 months with high-grade infection. Importantly, the presence of CMV in brain metastasis may open new treatment options as recently tests with Glioblastoma brain tumors have shown significant increases in survival by treating these highly prevalent CMV infected tumors with anti-virals like Valcyte.
Research also shows 94% of lymph node metastasis of breast cancer and 99% of brain metastasis of colorectal and breast cancers are CMV protein positive, but virus positivity is nearly absent in healthy surrounding tissues implying a viral presence in metastasis initiating cells.
Many factors contribute to Cancer, but the key catalyst (even the underlying engine) is one of many Viruses, particularly CMV, but also VZV, Epstein Barr as well as other Viruses SV-40, BK, JCV and HPV. Each cancer in our body has one to many viruses associated with it. Some key ones are HPV – Human Papilloma Virus causes Cervical, Anal, Mouth, Throat, Lung, Vaginal and Penile Cancers. Epstein Barr causes Lymphoma, JC Polyoma Virus causes Colon Cancer. Epstein Barr, HPV & CMV have all been associated with Breast Cancer, thus one reason for it’s prevalence. Now down to kids Cancer, Medulloblastoma Neuroblastoma and it’s 99% terminal twin cancer Glioblastoma. For these cancers its mainly CMV (Human Cytomegalovirus), though other viruses like SV-40, JC and BK are also capable and have been found in these tumors.
I’ve written often about the fact that 99% of Glioblastoma and 92% of Medulloblastoma show active CMV infections and show signs that CMV has hit and run certain tumor cells making genetic and epigenetic changes.
Now researchers are testing Neuroblastoma for CMV and the latest research shows 100% of the tumors showed signs of CMV or cyclomegalovirus. This continues to reinforce that brain cancers key consistent factor is the triggering of oncogenisis is by a viral infection that over expresses oncogenes and disables key anti-oncogenes thus driving these devastating cancers and leads towards potential opportunities for new and less devastating treatment options including using anti-virals like Valcyte.
Genes are biological chemical software routines that do specific tasks in our bodies. Oncogenes are genes that have been proven to contribute to the development and growth of cancer. There are approx. 50 distinct Oncogenes known and some that are found often over expressed in Medulloblastoma are MYC , MYCN and TAG. MYC and MYCN alone cause many hallmarks of cancer. When these genes are ran, they accelerate DNA replication, they turn off programmed cell death in two ways, drives new blood vessels to the cell / tumor and more (footnote ***).
Anti-Oncogenes are genes with the ability to police Oncogenes and keep them from going out of control and causing cancer (The most common damaged Medulloblastoma Anti-oncogene is P53 also known as TP53. There are two copies of TP53 and both must be damaged for this gene to be silenced (footnotes * **). When cancer happens, a couple basic things happen: