Archives For Breast Cancer

“During the last years increasing evidence implies that human cytomegalovirus (CMV) can be attributed to human malignancies arising from numerous tissues. In this perspective, we will review and discuss the potential mechanisms through which CMV infection may contribute to brain tumors by affecting tumor cell initiation, progression and metastasis formation. Recent evidence also suggests that anti-CMV treatment results in impaired tumor growth of CMV positive xenografts in animal models and potentially increased survival in CMV positive glioblastoma patients. Based on these observations and the high tumor promoting capacity of this virus, the classical and novel antiviral therapies against CMV should be revisited as they may represent a great promise for halting tumor progression and lower cancer deaths.”

CMV In Human Brain Tumors – World Journal Experimental Medicine

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The following article explains how CMV or Cytomegalovirus recreates the Hallmarks of Cancer. The following are all signs of cancer: high prevalence of cell growth signaling, evading and disabling growth suppression, resisting cell death procedures, thus enabling cell immortality, building new blood vessels and enabling invasion and thus metastasis.  Chronic inflammation also plays a role in cancer progression as well.  Now see Hallmark by Hallmark how CMV can recreate all of these drivers that together enable cancer.

The Oncogenicity of CMV Research

Brain metastases caused by solid tumors in others parts of the body and cause many cancer related deaths.  Human cytomegalovirus (HCMV or CMV) is recently been detected consistently using the latest methods reviewing brain metastases tumors from primary breast and colorectal cancers.

This report shows for the first time a very high prevalence of CMV infection in brain metastasis from both breast and colorectal cancers.  CMV proteins now being proven to drive cancers were detected in 99% (n = 78) brain metastasis samples and also in 92% to 100% (n = 25) of corresponding breast and colorectal cancer specimens.

Patients who had low-grade CMV infections in the primary tumor or the brain metastasis had a longer time to tumor progression and overall longer survival (13.5 months Overall Survivial with low-grade infection compared to 6.9 months with high grade infections).  Time to tumor progression was also longer with low-grade CMV infections at 65.1 months average versus 30 months with high-grade infection.  Importantly, the presence of CMV in brain metastasis may open new treatment options as recently tests with Glioblastoma brain tumors have shown significant increases in survival by treating these highly prevalent CMV infected tumors with anti-virals like Valcyte.

Research also shows 94% of lymph node metastasis of breast cancer and 99% of brain metastasis of colorectal and breast cancers are CMV protein positive, but virus positivity is nearly absent in healthy surrounding tissues implying a viral presence in metastasis initiating cells.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311044/

Vitamin D

Starting off, Vitamin D is not a Vitamin, long time ago mis-namer. It’s actually a Pro-Hormone – a precursor building block to hormones and it’s unbelievably important. It acts as a molecular switch activating at least 200 target genes in our bodies, thereby regulating gene expression. And many of these are the ON switches for our immune system! I only wish I knew then, what I know now.

Continue Reading…

 

Vitamin D

Vitamin D

Vitamin D3 Deficiency – A Global Perspective

“Higher serum levels of the main circulating form of vitamin D…, are associated with substantially lower incidence rates of colon, breast, ovarian, renal, pancreatic, aggressive prostate and other cancers.”

 

Vitamin D

Vitamin D

Use of Vitamin D3 In Clinical Practice

“Vitamin D significantly reduces all-cause mortality”

“Not only are such deficiencies common, and probably the rule, vitamin D deficiency is implicated in most of the diseases of civilization. ”

Vitamin D Deficiency

December 20, 2012 — 1 Comment

 

Vitamin D

Vitamin D

Vitamin D Deficiency

“Vitamin D deficiency is now recognized as a pandemic.

It has been suggested that adults with a Vitamin D3 level of < 50 nmol/L who were then followed for up to 19 years had a 30–50% increased risk of developing colorectal, breast, prostate, and many other cancers ”