“During the last years increasing evidence implies that human cytomegalovirus (CMV) can be attributed to human malignancies arising from numerous tissues. In this perspective, we will review and discuss the potential mechanisms through which CMV infection may contribute to brain tumors by affecting tumor cell initiation, progression and metastasis formation. Recent evidence also suggests that anti-CMV treatment results in impaired tumor growth of CMV positive xenografts in animal models and potentially increased survival in CMV positive glioblastoma patients. Based on these observations and the high tumor promoting capacity of this virus, the classical and novel antiviral therapies against CMV should be revisited as they may represent a great promise for halting tumor progression and lower cancer deaths.”
Archives For Viral Cancer
The following article explains how CMV or Cytomegalovirus recreates the Hallmarks of Cancer. The following are all signs of cancer: high prevalence of cell growth signaling, evading and disabling growth suppression, resisting cell death procedures, thus enabling cell immortality, building new blood vessels and enabling invasion and thus metastasis. Chronic inflammation also plays a role in cancer progression as well. Now see Hallmark by Hallmark how CMV can recreate all of these drivers that together enable cancer.
Brain metastases caused by solid tumors in others parts of the body and cause many cancer related deaths. Human cytomegalovirus (HCMV or CMV) is recently been detected consistently using the latest methods reviewing brain metastases tumors from primary breast and colorectal cancers.
This report shows for the first time a very high prevalence of CMV infection in brain metastasis from both breast and colorectal cancers. CMV proteins now being proven to drive cancers were detected in 99% (n = 78) brain metastasis samples and also in 92% to 100% (n = 25) of corresponding breast and colorectal cancer specimens.
Patients who had low-grade CMV infections in the primary tumor or the brain metastasis had a longer time to tumor progression and overall longer survival (13.5 months Overall Survivial with low-grade infection compared to 6.9 months with high grade infections). Time to tumor progression was also longer with low-grade CMV infections at 65.1 months average versus 30 months with high-grade infection. Importantly, the presence of CMV in brain metastasis may open new treatment options as recently tests with Glioblastoma brain tumors have shown significant increases in survival by treating these highly prevalent CMV infected tumors with anti-virals like Valcyte.
Research also shows 94% of lymph node metastasis of breast cancer and 99% of brain metastasis of colorectal and breast cancers are CMV protein positive, but virus positivity is nearly absent in healthy surrounding tissues implying a viral presence in metastasis initiating cells.
There are now several trials where they are teaching the immune system to attack the CMV virus and thus leads the immune system to the cancer. This one is for Glioblastoma Brain Cancer. This shows once again the correlations of cancer and viruses.
This is exciting research as it adds additional hope to fight cancer without today’s toxic, poor outcomes and long term damaging standard protocols.
Many factors contribute to Cancer, but the key catalyst (even the underlying engine) is one of many Viruses, particularly CMV, but also VZV, Epstein Barr as well as other Viruses SV-40, BK, JCV and HPV. Each cancer in our body has one to many viruses associated with it. Some key ones are HPV – Human Papilloma Virus causes Cervical, Anal, Mouth, Throat, Lung, Vaginal and Penile Cancers. Epstein Barr causes Lymphoma, JC Polyoma Virus causes Colon Cancer. Epstein Barr, HPV & CMV have all been associated with Breast Cancer, thus one reason for it’s prevalence. Now down to kids Cancer, Medulloblastoma Neuroblastoma and it’s 99% terminal twin cancer Glioblastoma. For these cancers its mainly CMV (Human Cytomegalovirus), though other viruses like SV-40, JC and BK are also capable and have been found in these tumors.
It’s been over two and a half years since Ayden was diagnosed with Medulloblastoma and I started this research journey. Lots of dead ends trying to separate the wheat from the chaff. Then reading too many PubMed articles to imagine, I narrowed Ayden’s cancer to a CMV driven cancer. I finally am seeing others write-up this same conclusion. Finally the ball is gaining momentum and people are living longer due to this new course of treatment. Next up, move beyond Glioblastoma, and begin running clinical trials with Medulloblastoma, Neuroblastoma, Prostate, Lung and Breast cancer. Then we need to look at CMV and other opportunistic pathogens as drivers of late term effects of all cancer survivors.