Genes are biological chemical software routines that do specific tasks in our bodies. Oncogenes are genes that have been proven to contribute to the development and growth of cancer. There are approx. 50 distinct Oncogenes known and some that are found often over expressed in Medulloblastoma are MYC , MYCN and TAG. MYC and MYCN alone cause many hallmarks of cancer. When these genes are ran, they accelerate DNA replication, they turn off programmed cell death in two ways, drives new blood vessels to the cell / tumor and more (footnote ***).
Anti-Oncogenes are genes with the ability to police Oncogenes and keep them from going out of control and causing cancer (The most common damaged Medulloblastoma Anti-oncogene is P53 also known as TP53. There are two copies of TP53 and both must be damaged for this gene to be silenced (footnotes * **). When cancer happens, a couple basic things happen:
1) Oncogenes get ran (or transcripted) when they shouldn’t and too often. Many different paths are used to trigger these Oncogenes depending on the cancer types. The first section of a gene is where the scheduler is located for when and why the gene should run. This area often gets reprogrammed in cancer. This change to the scheduler for a gene is called an Epigenic change. If the actual gene main code gets damaged, mutated or copied over, it’s a genetic change.
2) Anti-Oncogenes get silenced / mutated / copied over (Genetic defects) or reprogrammed so they can no longer control the now unregulated and over expressed Oncogenes and Cancer cells grow out of control (Epigenetic Defects)
3) Multiple and Consistent Defects: It appears to take both of these events for cancer to grow out of control with Genetic and Epigenetic manipulation.
4) The Human Genome includes complex biological building blocks to build every part of a human and have many checks and balances to insure it goes well for a long lifetime. Yet there are situations that cause Oncogenes to run uncontrolled and the police of Oncogenes (anti-oncogenes) to be silenced by many different and seemingly creative means.
It should be heavily noted that the human genome has approximately 20,000 genes, yet repeatedly with sub-types of cancers have somehow enabled the running of unregulated oncogenes aggressively and anti-oncogenes get silenced. It should also be clear that while the Anti-oncogenes patrol and control oncogenes, they are not located adjacent to each other, actually quite a distance away, yet the same over enabling of one and disabling of another happens consistently for specific cancer sub-types. Sometimes the gene is reprogrammed, sometimes it is copied over, sometimes it is mutated and damaged or mutated and made more aggressive. The unique ways these changes are made and the repeated way it happens specifically to the same critical locations around growth control and growth management is far beyond coincidence. Something is intentionally causing these genetic and epigenetic changes in the human genome. Understanding what would benefit from these changes gives us insight in to what is changing them, why and thus new targets to defeat this enemy from within.
When you take in the above knowledge, it makes you wonder, what defects can cause such specific damage to a living thing including humans. Does smoking cause one gene to be disabled and another in a different part of the genome get turned on really fast? How about chemo? how about eating poorly? Asbestos? The sun? or any number of other issues that are considered carcinogenic. Clearly they damage, clearly they make us weaker and more susceptible to injury and health decline, but do they cause these specific defects? This is a very key question. Because without asking this key question, we take for granted that they do and we stop looking for the likely real root cause, thus the real solutions.
So, if these carcinogens can’t be found to cause the real core cause of cancer, then what does.
This is where my hypothesis of viruses causing cancer comes in, i’ll list off general issues here because the specifics get messy and will confuse the issues, but I have backup for all the specifics:
a) Viruses consistently cut and paste genetic material in all living things including humans.
b) Herpes viruses including CMV, EBV, Varcella Zoster, Herpes Simplex Viruses, Roseolovirus, Kaposi’s Sarcoma associated herpes virus and the HPV, JC Virus, BK Virus, SV-40 Viruses many of them have been associated with Medulloblastoma or Cerebellum defects, or at minimum many head and neck cancers. CMV & JC Virus the most prominent Medulloblastoma associated viruses (92% and 60% respectively found in recent Medulloblastoma genetic tumor samples), while Varcella Zoster is known to cause all symptoms of PFS and HPV is known to cause many other Head and Neck Cancers. The right answer is to test our kids for all of these, but there just aren’t any test made to test all of these and some are extremely difficult to find when you do test. Again, these viruses are very good at hiding, growing, surviviing so even with all our knowledge we can’t always find them, can’t kill them since they setup life long infections and only know are we learning ways to slow them down.
c) These viruses all have tools to replicate inside human cells. How and what tools these viruses use to drive their replication is of extreme importance. Several of these viruses are known to over express Oncogenes including and specifically MYC & MYCN. Several of these genes have been found to copy genetic content onto Chromosome 17 damaging P53 anti-oncogene. Some of these viruses have been found to Epigenetically reprogram P53 and other Anti-Oncogenes to turn off. These viruses use these pathways to aid in their replication. If a virus takes over a host cell and over expresses that cell’s oncogens, that cell is going to stop dying and start replicating at a very fast and uncontrolled pace and it won’t die like it should making more viral controlled cells (very much like cancer). Viruses expressing Oncogenes have their infected host cells attempted to be silenced by Anti-oncogenes. This has been scientifically researched to happen and for these viruses to have the ability to silence these anti-oncogenes, again, just like cancer. In both these cases, it’s the same genes being manipulated. This goes beyond coincidence.
Important point, The viruses I have listed above are extremely prevalent in the human body. In a healthy individual with a fully functioning immune system, our bodies usually can fight off many viruses and clear them from our bodies quickly or within a year or so. Some of these viruses are just extremely tenacious and defeat our immune system, but go into a repeated pattern of hiding for a while, then going active, replicating, causing more damage, then going latent again. These ongoing attacks further weaken our bodies.
Some of these viruses have specialties. Some of them turn on MYC for example. Another will turn off P53 one way or another. If each virus takes on one task and accomplishes it in the same location, you have an unregulated cell that now will begin replicating without controls, can summon blood vessels to drive food to the cells and a tumor is created.
Cancer is very complicated, I have cut out many additional defects, complexities, but sorting the forests from the trees, Viruses are present, have the motive and the ability to cause cancer. It may take more than one virus to cause enough defects to set off the chain reaction of cancer. It may take a damaged immune system like a Vitamin D deficiency and/or a defected P53 or similar Anti-Oncogene genetic defect due to the child’s parents passing on previous viral damage or the egg being attacked by a virus before major replication begins, damage from carcinogens that weaken the cells of the bodies defenses from viral attacks so that they happen more often upping the odds for the virus to cause genetic and epigenetic defects to further its growth. Increases the viruses ability to drive Cox-2 inflammation across the body including the cancers tumor location, but also to our hearts, lungs, thyroids, kidneys, etc likely driving secondary failures that are pinned on cancer treatment (instead of on viruses taking advantage of all the damage from cancer treatment).
For those of you that have the beginning of belief that I may really be on to something, you ask, what do I do now? This has been the most vexing problem for me after the unraveling of this mystery and the challenges of documenting it.
First, our kids need a strong immune system. Oncologists on the whole don’t either believe or practice nutrition. Likely before, and for sure after treatment, our kids nutritional balance has been severely damaged. Higher a Oncology Nationalist like Nutrional Solutions ASAP is a great place to start: http://www.nutritional-solutions.net/ Either way, getting your Vitamin D from extremely low (likely) to therapeutic levels is essential. https://youcancatchcancer.com/2013/02/24/vitamin-d-disease-prevention/ Keep in mind that Vitamin D3 has now been shown to turn down the Oncogene MYC! This is research from late last year. This is fantastic news. One possible warning. I gave Ayden Vitamin D3 all through chemo with many positive results. But, since Vitamin D3 down regulates MYC Oncogene within 24 hours of a dose, it turns down the growth of cancer if it’s being regulated by MYC. Since many of the chemo and radiation treatments count on killing fast replicating cells, it’s possible that Vitamin D is inadvertently protecting the cells by slowing down their replication. Something to consider during active treatment. Do you stop taking Vitamin D just before treatments and resume right after? I wish someone smarter than me would figure this out. All I can do is share what I find as I learn it.
There are many other supplements that can help boost the immune system that can be considered, some of I have researched and began utilizing include L-Lysine since it is made in the body, but not enough with our diets. It’s an amino acid that slows the replication of viruses. Milk Thistle, has been known to have some anti-cancer properties, but I focused on it’s ability to help repair and clean out the kidneys and liver so they process toxins out of the body faster reducing long term toxicity and less toxicity should equal a more healthy body. Probiotics since science is determining that much of our immune system seems to come from our GI tract and the chemo, radiation and a year and a half of anti-biotics destroys the flora in our bodies protecting our GI track, dramatically reduces our ability to break down food and pull out the nutrients, less nutrients and our kids get malnutrition further weakening them and finally, no protection for our GI tracks causes these problems to become long term problems, pain in the GI track, etc down a slippery slope of secondary problems.
Finally, once we know what viruses we are dealing with, there are some, not many, but some prescription anti-virals that can be taken by IV or by pill form. Monthly like a Valtrex or very strong Anti-viral IV versions like Valacyclovir. An interesting point is that trials are now happening using Valacyclovir (an anti-viral) to battle brain cancer (glioblastoma so far) with the ability do half the tumor size and double the life expectency of a Glioblastoma patient. Additional research has been done on Medulloblastoma samples in vitro (not yet in the human body) that uses methods to block epigenetic changes from triggering anti-oncogene silencing. So far the research has shown great promise by stopping Medulloblastoma growth and turning back on programmed cell death so the tumor starts dying and as a added benefit, the same treatment stops viral replication. This truly is a great direction in the treatment of cancer.
Backup for most of this is here: https://youcancatchcancer.com/2013/05/25/oncogenisis-focus-on-brain-cancers-viral-link/
I’m working on referencing the sources on the rest in the next week since I’ve got another presentation with my kids hospital research wing. The cool part is they actually asked for me to come in and present it to them. Clearly “Hell is Freezing Over”.
Gary “Ayden’s Dad”
Some footnotes worth understanding:
* – Unfortunately somehow it’s possible to be born with one of the TP53 Anti-oncogenes missing or damaged and this dramatically increases the chance for cancer during life by 25X. This defect is called Li-Fraumeni syndrome. Li–Fraumeni syndrome is characterized by:
• several kinds of cancer are involved;
• cancer often appears at a young age; and,
• cancer often appears several times throughout the life of an affected person.
** – Some of you will see on your genetics testing that Chromosome 17p has been damaged or copied over by 17q. Well 17p is where P53 Anti-oncogene is located. As stated earlier, P53 is the most mutated Tumor Suppressor Gene, not only in Medulloblastoma, but in all cancers, P53 is the most silenced gene. We are now learning, besides being damaged by rogue copy and paste errors, this area can also be reprogrammed to silence this extremely important area. Clearly there are forces at work trying to turn off this gene one way or another.
*** – MYC and other Oncogenes are also found inside many viruses. Some are copies of the genes in humans, some are mutated more aggressive forms. The v-MYC viral Oncogene for example can cause tumors to grow within days of entry into a host cell. This is not hypothesis, this is proven fact.